How it Works

Immune Health Basics™ with Wellmune WGP® is the only nutritional supplement that is scientifically proven to enhance the immune system, as evidence by research both demonstrating its mechanism of action in the body and measuring significant changes in immune response. In fact, the science supporting the efficacy of Wellmune WGP is overwhelming.

 

Wellmune WGP is a natural gluco polysaccharide derived from the cell walls of a highly purified, proprietary yeast (Saccharomyces cerevisiae). This unique ingredient triggers human immune defenses that have evolved over thousands of years to protect the body.

The scientific understanding of Wellmune WGP's mechanism of action in the body is well documented in published, peer-reviewed research. Mechanism of action studies as well as measurement of significant changes in immune responses are changing the way researchers and physicians think about innate immune function.

 

Once swallowed, immune cells in the gastrointestinal tract take up Wellmune WGP and transport it to immune organs throughout the body. While in the immune organs, immune cells called macrophages digest Wellmune WGP into smaller fragments and slowly release them over a number of days. The fragments bind to neutrophils, via complement receptor 3 (CR3), which are the most abundant immune cells in the body. In fact, neutrophils account for 60-70% of all immune cells.

Activated by Wellmune WGP, the neutrophils now more quickly navigate to the site of a foreign challenge and kill it. Unlike other immune health ingredients, Wellmune WGP enhances immune function without stimulating the immune system. Immune boosters or stimulators may be harmful and cause autoimmune disease.

 

Researchers discovered the mechanism through a series of experiments. One study involved tracking fluorescently dyed Wellmune WGP as immune cells transport it throughout the body (Figure 1). Within days Wellmune WGP is carried to the spleen, bone marrow and other immune organs.

In a separate study, significant improvement was observed in the killing activity of immune cells (Figure 2).Phagocytic cells, which literally engulf and destroy foreign challengers, showed greater microbial killing in subjects who had taken Wellmune WGP.